Unexplained infertility – in unexplained infertility where we cannot identify any cause of infertility after thorough testing, IUI may be recommended as a treatment option. It provides a more controlled environment for sperm to reach the egg compared to natural conception.

Donor sperm IUI – if the male has azoospermia (absence of sperms in the semen) pregnancy can be achieved using donor sperm. The sperm is carefully selected, processed, and then inseminated into the woman's uterus during her fertile period.

Mild male factor - If semen parameters are mildly deranged like, slightly lower sperm count, reduced sperm motility, or minor abnormalities in sperm shape (morphology), IUI can be helpful by concentrating the healthy sperms and delivering them directly into the uterine cavity, thus bypassing certain hindrances which come in the path of the sperms.

Sexual dysfunction – some couples may have difficulties during intercourse due to pain, erectile dysfunction, or some other issues. So IUI provides an alternative method of depositing sperms into the vagina or uterine cavity without relying solely on intercourse for achieving pregnancy.

Ovulation problems – if the female partner is not forming an egg (anovulation) or has irregular ovulation, IUI can be combined with ovulatory medications, such as oral or injectable, to stimulate the ovaries for egg formation and increase the chances of successful ovulation, fertilization, and pregnancy.

Cervical factor  - In a few females, the cervix may produce hostile mucus, which can hinder the motility of the sperms or prevent the sperms from entering the uterus. IUI bypasses the cervix, placing the sperm directly into the uterine cavity, overcoming the hostile mucus.